HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → [4-(2-Methoxy-ethyl)-piperazin-1-yl]-benzoic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | [4-(2-Methoxy-ethyl)-piperazin-1-yl]-benzoic acid methyl ester | HCID 69996255 | — |
| Product | [4-(2-Methoxy-ethyl)-piperazin-1-yl]-benzoic acid hydrochloride | HCID 69130178 | — |
Reaction Steps
[4-(2-methoxy-ethyl)-piperazin-1-yl]-benzoic acid methyl ester (17 mmol) is dissolved in 4N HCl (70 ml) and heated under reflux for 5 hours. After cooling the solvent is evaporated and the residue is suspended in ethanol and the solid filtered of, washed with diethylether and dried (vacuum). A powder with mp. >270° C., Rf=0.35 (CH2Cl2/MeOH=9:1) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642239B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-e885f860ff0c4f559cf84f0bd45bf083 |
| Source note | uspto-grants-2003_11 |