反应详情

[4-(2-methoxy-ethyl)-piperazin-1-yl]-benzoic acid methyl ester (17 mmol) is dissolved in 4N HCl (70 ml) and heated under reflux for 5 hours. After cooling the solvent is evaporated and the residue is suspended in ethanol and the solid filtered of, washed with diethylether and dried (vacuum). A powder with mp. >270° C., Rf=0.35 (CH2Cl2/MeOH=9:1) is obtained.

1. temperatureheated
2. temperatureunder reflux for 5 hours
3. temperatureAfter cooling the solvent
4. customis evaporated
5. filtrationthe solid filtered of,
6. washwashed with diethylether
7. customdried (vacuum)
8. customA powder with mp. >270° C., Rf=0.35 (CH2Cl2/MeOH=9:1) is obtained