反应详情

4-Phenylpiperidine (87 mmol) and pyridine (96 mmol) are dissolved in dry CH2Cl2 (100 ml) and acetylchloride (96 mmol) in CH2Cl2 (40 ml) is added dropwise to the stirred solution at 10° C. The reaction is stirred for 1 hour at rt. The mixture is extracted three times with water and the water phase is extracted again with CH2Cl2. The combined organic phases are dried over sodium sulfate and evaporated. A pale brown oil with Rf=0.13 (ethyl acetate/hexane=1:1) is obtained.

1. extractionThe mixture is extracted three times with water
2. extractionthe water phase is extracted again with CH2Cl2
3. dry with materialThe combined organic phases are dried over sodium sulfate
4. customevaporated
5. customA pale brown oil with Rf=0.13 (ethyl acetate/hexane=1:1) is obtained