Hydrochloric Acid → 4-(1-Propyl-piperidin-4-yl)-benzoic acid hydrochloride

HRID 478642Notes

Reaction equation

HRID 478642 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH3:18])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[ClH:20]>>[ClH:20].[CH2:16]([N:13]1[CH2:12][CH2:11][CH:10]([C:7]2[CH:6]=[CH:5][C:4]([C:3]([OH:19])=[O:2])=[CH:9][CH:8]=2)[CH2:15][CH2:14]1)[CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 69129839HCID 69129839, compound

Product 1

HCID 691302054-(1-Propyl-piperidin-4-yl)-benzoic acid hydrochloride

Conditions

Temperature
2 °C

Procedure

4-(1-Propyl-piperidin-4-yl)-benzoic acid methyl ester (32 mmol) is dissolved in 4N HCl (45 ml) and heated under reflux for 7 hours. The mixture is cooled in an ice bath to 0-4° C. and the solid material formed is filtered off, washed with cold acetone and dried (vacuum). A brown powder with mp. >270° C., Rf=0.08 (CH2Cl2/MeOH=9:1) is obtained.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 7 hours
  3. customthe solid material formed
  4. filtrationis filtered off
  5. washwashed with cold acetone
  6. customdried (vacuum)
  7. customA brown powder with mp. >270° C., Rf=0.08 (CH2Cl2/MeOH=9:1) is obtained

Sources & evidence

ORD record
ord-edfdd774c5724a3eb07fc43d78910dfe
Source dataset
uspto-grants-2003_11
Patent number
US06642239B2

Reaction notes

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