反应详情

温度

2 °C

4-(1-Propyl-piperidin-4-yl)-benzoic acid methyl ester (32 mmol) is dissolved in 4N HCl (45 ml) and heated under reflux for 7 hours. The mixture is cooled in an ice bath to 0-4° C. and the solid material formed is filtered off, washed with cold acetone and dried (vacuum). A brown powder with mp. >270° C., Rf=0.08 (CH2Cl2/MeOH=9:1) is obtained.

1. temperatureheated
2. temperatureunder reflux for 7 hours
3. customthe solid material formed
4. filtrationis filtered off
5. washwashed with cold acetone
6. customdried (vacuum)
7. customA brown powder with mp. >270° C., Rf=0.08 (CH2Cl2/MeOH=9:1) is obtained