HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[1-(2-Methoxy-ethyl)-piperidin-4-yl]-benzoic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 4-(1-(2-methoxyethyl)piperidin-4-yl)benzoate | HCID 66589759 | — |
| Product | 4-[1-(2-Methoxy-ethyl)-piperidin-4-yl]-benzoic acid hydrochloride | HCID 69130206 | — |
Reaction Steps
4-[1-(2-Methoxy-ethyl)-piperidin-4-yl]-benzoic acid methyl ester (47 mmol) is dissolved in 4N HCl (80 ml) and heated under reflux for 12 hours. After cooling the solvent is evaporated and the residue is suspended in acetone and the solid filtered of, washed with acetone and dried (vacuum). A white powder with mp. >270° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642239B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-a6da4b603e514c898ec0206a6b056e1c |
| Source note | uspto-grants-2003_11 |