反应详情

4-[1-(2-Methoxy-ethyl)-piperidin-4-yl]-benzoic acid methyl ester (47 mmol) is dissolved in 4N HCl (80 ml) and heated under reflux for 12 hours. After cooling the solvent is evaporated and the residue is suspended in acetone and the solid filtered of, washed with acetone and dried (vacuum). A white powder with mp. >270° C. is obtained.

1. temperatureheated
2. temperatureunder reflux for 12 hours
3. temperatureAfter cooling the solvent
4. customis evaporated
5. filtrationthe solid filtered of,
6. washwashed with acetone
7. customdried (vacuum)
8. customA white powder with mp. >270° C. is obtained