Hydrochloric Acid → 4-[1-(2-Methoxy-ethyl)-piperidin-4-yl]-benzoic acid hydrochloride

HRID 478645Notes

Reaction equation

HRID 478645 reaction equation
C[O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][O:18][CH3:19])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[ClH:21]>>[ClH:21].[CH3:19][O:18][CH2:17][CH2:16][N:13]1[CH2:12][CH2:11][CH:10]([C:7]2[CH:6]=[CH:5][C:4]([C:3]([OH:20])=[O:2])=[CH:9][CH:8]=2)[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 66589759Methyl 4-(1-(2-methoxyethyl)piperidin-4-yl)benzoate

Product 1

HCID 691302064-[1-(2-Methoxy-ethyl)-piperidin-4-yl]-benzoic acid hydrochloride

Procedure

4-[1-(2-Methoxy-ethyl)-piperidin-4-yl]-benzoic acid methyl ester (47 mmol) is dissolved in 4N HCl (80 ml) and heated under reflux for 12 hours. After cooling the solvent is evaporated and the residue is suspended in acetone and the solid filtered of, washed with acetone and dried (vacuum). A white powder with mp. >270° C. is obtained.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 12 hours
  3. temperatureAfter cooling the solvent
  4. customis evaporated
  5. filtrationthe solid filtered of,
  6. washwashed with acetone
  7. customdried (vacuum)
  8. customA white powder with mp. >270° C. is obtained

Sources & evidence

ORD record
ord-a6da4b603e514c898ec0206a6b056e1c
Source dataset
uspto-grants-2003_11
Patent number
US06642239B2

Reaction notes

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