Hydrochloric Acid → HCID 69129801, compound

HRID 478647Notes

Reaction equation

HRID 478647 reaction equation
I.C[O:3][C:4](=[O:20])[C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:16][CH2:15][N:14]([CH:17]([CH3:19])[CH3:18])[CH2:13][CH2:12]2)=[CH:7][CH:6]=1.[ClH:21]>>[ClH:21].[CH:17]([N:14]1[CH2:13][CH2:12][CH:11]([C:8]2[CH:7]=[CH:6][C:5]([C:4]([OH:20])=[O:3])=[CH:10][CH:9]=2)[CH2:16][CH2:15]1)([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 69130193HCID 69130193, compound

Product 1

HCID 69129801HCID 69129801, compound

Procedure

4-(1-Isopropyl-piperidin-4-yl)-benzoic acid methyl ester hydroiodide (1.7 mmol) is dissolved in 4N HCl (5 ml) and heated under reflux for 10 hours. After cooling the solvent is evaporated and the residue is suspended in acetone and the solid filtered of, washed with acetone and dried (vacuum). A grey-brown powder with mp. >270° C. is obtained.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 10 hours
  3. temperatureAfter cooling the solvent
  4. customis evaporated
  5. filtrationthe solid filtered of,
  6. washwashed with acetone
  7. customdried (vacuum)
  8. customA grey-brown powder with mp. >270° C. is obtained

Sources & evidence

ORD record
ord-e8c52e750af84d7db15b694bdc71f61d
Source dataset
uspto-grants-2003_11
Patent number
US06642239B2

Reaction notes

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