Hydrochloric Acid → 4-(1-Methylpiperidin-4-yl)benzoic acid hydrochloride

Participants

Reaction Steps

4-(1-Methyl-piperidin-4-yl)-benzoic acid methyl ester (4.55 mmol) is dissolved in 4N HCl (10 ml) and heated under reflux for 8 hours. After cooling the solvent is evaporated and the residue is suspended in acetone and the solid filtered of, washed with acetone and dried (vacuum). A pale-brown powder with mp. >270° C. is obtained.

Provenance & Evidence