Hydrochloric Acid → 4-(1-methyl-4-piperidinyl)Benzoic acid hydrochloride

HRID 478652Notes

Reaction equation

HRID 478652 reaction equation
C[O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[ClH:18]>>[ClH:18].[CH3:16][N:13]1[CH2:14][CH2:15][CH:10]([C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:17])=[O:2])=[CH:5][CH:6]=2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 49760144Methyl 4-(1-methylpiperidin-4-YL)benzoate

Product 1

HCID 691298094-(1-methyl-4-piperidinyl)Benzoic acid hydrochloride

Procedure

4-(1-Methyl-piperidin-4-yl)-benzoic acid methyl ester (4.55 mmol) is dissolved in 4N HCl (10 ml) and heated under reflux for 8 hours. After cooling the solvent is evaporated and the residue is suspended in acetone and the solid filtered of, washed with acetone and dried (vacuum). A pale-brown powder with mp. >270° C. is obtained.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 8 hours
  3. temperatureAfter cooling the solvent
  4. customis evaporated
  5. filtrationthe solid filtered of,
  6. washwashed with acetone
  7. customdried (vacuum)
  8. customA pale-brown powder with mp. >270° C. is obtained

Sources & evidence

ORD record
ord-0e5cfb0025fb4a84b76719c0ba8f30a3
Source dataset
uspto-grants-2003_11
Patent number
US06642239B2

Reaction notes

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