反应详情

4-(1-Methyl-piperidin-4-yl)-benzoic acid methyl ester (4.55 mmol) is dissolved in 4N HCl (10 ml) and heated under reflux for 8 hours. After cooling the solvent is evaporated and the residue is suspended in acetone and the solid filtered of, washed with acetone and dried (vacuum). A pale-brown powder with mp. >270° C. is obtained.

1. temperatureheated
2. temperatureunder reflux for 8 hours
3. temperatureAfter cooling the solvent
4. customis evaporated
5. filtrationthe solid filtered of,
6. washwashed with acetone
7. customdried (vacuum)
8. customA pale-brown powder with mp. >270° C. is obtained