Fumaric Acid → HCID 86589625, compound

HRID 478662Notes

Reaction equation

HRID 478662 reaction equation
[CH2:1]1[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:3][CH:2]1[N:10]1[CH2:26][CH2:25][C:13]2([N:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:16][CH2:15][CH:14]2[OH:24])[CH2:12][CH2:11]1.[C:27]([O-:34])(=[O:33])/[CH:28]=[CH:29]/[C:30]([O-:32])=[O:31].C(O)(=O)/C=C/C(O)=O>C(OCC)C>[C:27]([OH:34])(=[O:33])/[CH:28]=[CH:29]/[C:30]([OH:32])=[O:31].[CH2:1]1[CH:9]2[CH:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)[CH2:3][CH:2]1[N:10]1[CH2:26][CH2:25][C:13]2([N:17]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:16][CH2:15][C:14]2=[O:24])[CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 444972Fumaric AcidHCID 5460307FumarateHCID 18002526HCID 18002526, compound

Product 1

HCID 86589625HCID 86589625, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Oxidation of 8-(octahydro-inden-2-yl)-1-phenyl-1,8-diaza-spiro[4.5]decan-4-ol (mixture of diastereoisomers) according to the general method of example 20 and formation of the fumarate with fumaric acid in diethyl ether yielded the title compound, pale brown solid, m.p. 225° C. and MS: m/e=353.4 (M+H+).

Sources & evidence

ORD record
ord-499ff35c5cab4675930b69ff418b33c3
Source dataset
uspto-grants-2003_11
Patent number
US06642247B2

Reaction notes

Loading…