HCID 12711388, compound → HCID 18002557, compound

HRID 478666Notes

Reaction equation

HRID 478666 reaction equation
C([N:8]1[CH2:24][CH2:23][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][CH2:13][CH:12]2[OH:22])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.C(OC(=O)C)C.[Pd]>[C:16]1([N:15]2[C:11]3([CH2:23][CH2:24][NH:8][CH2:9][CH2:10]3)[CH:12]([OH:22])[CH2:13][CH2:14]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 1

HCID 12711388HCID 12711388, compound

Product 1

HCID 18002557HCID 18002557, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

(RS)-8-Benzyl-1-phenyl-1,8-diaza-spiro[4.5]decan-4-ol (7.8 mmol) was dissolved in methanol (100 ml) and ethylacetate (100 ml). Palladium on carbon (10%, 0.2 g) was added and the mixture was hydrogenated at room temperature and normal pressure. Filtration and evaporation yielded the desired product. 1.8 g (99%) (RS)-1-phenyl-1,8-diaza-spiro[4.5]decan-4-ol as a beige solid, m.p. 141-144° C. and MS: m/e=232 (M+).

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-020f5704a77c4530a41a20a5df7ac592
Source dataset
uspto-grants-2003_11
Patent number
US06642247B2

Reaction notes

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