Aniline → HCID 178448106, compound

HRID 478669Notes

Reaction equation

HRID 478669 reaction equation
[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@H:7]([N:10]2[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CCCCC>[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@H:7]([N:10]2[CH2:15][CH2:14][C:13](=[N:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6115AnilineHCID 178448108HCID 178448108, compound

Product 1

HCID 178448106HCID 178448106, compound

Reagents, catalysts & solvents 1

HCID 8003PentaneSolvent

Procedure

cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-one (5.0 g, 23.4 mmol), aniline (3.3 g, 35.3 mmol) and molecular sieves (20 g, 4A) were stirred in 100 ml pentane at room temperature for 6 days. The molecular sieves were filtered off and the solvent was evaporated. The crude product was used without any further purification.

Workup

  1. filtrationThe molecular sieves were filtered off
  2. customthe solvent was evaporated
  3. customThe crude product was used without any further purification

Sources & evidence

ORD record
ord-f91152ed81a84337b15e39ccd64a81fe
Source dataset
uspto-grants-2003_11
Patent number
US06642247B2

Reaction notes

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