Chloroacetonitrile → 6-Methyl-2-(3-nitrophenylamino)nicotinic acid cyanomethyl ester

Participants

Reaction Steps

To a suspension of 6-methyl-2-(3-nitrophenylamino)-nicotinic acid (15.06 g, 55.11 mmol) in acetone (220ml) was added triethylamine (6.13 g, 60.6 mmol) and chloroacetonitrile (4.58 g, 60.6 mmol), and the mixture was heated under reflux overnight. The reaction mixture was filtered to remove an insoluble. The filtrate was evaporated. The resultant residue was washed successively with 1N aqueous sodium hydroxide and water, and dried to give 6-methyl-2-(3-nitrophenylamino)nicotinic acid cyanomethyl ester (15.44 g, 90%).

Provenance & Evidence