反应详情

To a suspension of 6-methyl-2-(3-nitrophenylamino)-nicotinic acid (15.06 g, 55.11 mmol) in acetone (220ml) was added triethylamine (6.13 g, 60.6 mmol) and chloroacetonitrile (4.58 g, 60.6 mmol), and the mixture was heated under reflux overnight. The reaction mixture was filtered to remove an insoluble. The filtrate was evaporated. The resultant residue was washed successively with 1N aqueous sodium hydroxide and water, and dried to give 6-methyl-2-(3-nitrophenylamino)nicotinic acid cyanomethyl ester (15.44 g, 90%).

1. temperaturethe mixture was heated
2. temperatureunder reflux overnight
3. filtrationThe reaction mixture was filtered
4. customto remove an insoluble
5. customThe filtrate was evaporated
6. washThe resultant residue was washed successively with 1N aqueous sodium hydroxide and water
7. customdried