3-Pyridinecarboxaldehyde → Ethyl 3-(3-Pyridyl)propanoate

HRID 478728Notes

Reaction equation

[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.C(OP([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])(OCC)=O)C>>[N:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH2:1][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:3]=1

Participants

Reactant 2

HCID 103713-Pyridinecarboxaldehyde

HCID 13345Triethyl phosphonoacetate

Product 1

HCID 3736947Ethyl 3-(3-Pyridyl)propanoate

Procedure

The procedure of Synthetic Example 4 was repeated using nicotinaldehyde and ethyl diethylphosphonoacetate to obtain ethyl 3-(pyridin-3-yl)propionate.

Sources & evidence

ORD record: ord-cb4e96cd0ed9447394ae7bc73bd92284
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06642250B2

Reaction notes

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