Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl (ethoxymethylene)malonate → Ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 반응물 | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| 용매 | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| 생성물 | Ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 3018009 | — |
반응 단계
A mixture of 3-chloro-4-fluoroaniline (1) (87.3 g) and diethyl ethoxymethylene malonate (129.7 g) and Dowtherm (700 mL) (diphenyl ether) was refluxed for 4 h. It was cooled and the resulting solid was removed by filtration. The solid was recrystallized from DMF to give 55.O g (4). m.p.=>300° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699989B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-d039189b184e4c6c9444621fea33de2b |
| 출처 메모 | uspto-grants-2004_03 |