Potassium Carbonate → HCID 9821199, compound

Participants

Reaction Steps

NaN3 (0.20 g) and K2CO3 (0.78 g) were added to DMF (5 ml) solution of 6-chloromethyl-N-cyclohexyl-N-methylthiazolo[3,2-a]benzoimidazole-2-carboxamide hydrochloride (0.15 g) produced from the compound of Example 63 in the same manner as described in Example 75, and the mixture was stirred at 80° C. for 15 hours, mixed with a catalytically effective amount of Bu4NI and stirred at 80° C. for 8 hours and then at 120° C. for 15 hours. After cooling, the reaction solution was poured into water and extracted with EtOAc. After drying with MgSO4, the solvent was evaporated to obtain the title compound (0.14 g).

Provenance & Evidence