Potassium Carbonate → HCID 9821199, compound

HRID 478848Notes

Reaction equation

HRID 478848 reaction equation
[N-]=[N+]=[N-].[Na+].[C:5]([O-:8])([O-])=O.[K+].[K+].Cl.[Cl:12]C[C:14]1[CH:15]=[CH:16][C:17]2[N:21]=[C:20]3[S:22][C:23]([C:25]([N:27]([CH:29]4[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]4)[CH3:28])=[O:26])=[CH:24][N:19]3[C:18]=2[CH:35]=1>CN(C=O)C>[ClH:12].[CH:29]1([N:27]([CH3:28])[C:25]([C:23]2[S:22][C:20]3=[N:21][C:17]4[CH:16]=[CH:15][C:14]([CH2:5][OH:8])=[CH:35][C:18]=4[N:19]3[CH:24]=2)=[O:26])[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 33557Sodium AzideHCID 18003030HCID 18003030, compound

Product 1

HCID 9821199HCID 9821199, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

NaN3 (0.20 g) and K2CO3 (0.78 g) were added to DMF (5 ml) solution of 6-chloromethyl-N-cyclohexyl-N-methylthiazolo[3,2-a]benzoimidazole-2-carboxamide hydrochloride (0.15 g) produced from the compound of Example 63 in the same manner as described in Example 75, and the mixture was stirred at 80° C. for 15 hours, mixed with a catalytically effective amount of Bu4NI and stirred at 80° C. for 8 hours and then at 120° C. for 15 hours. After cooling, the reaction solution was poured into water and extracted with EtOAc. After drying with MgSO4, the solvent was evaporated to obtain the title compound (0.14 g).

Sources & evidence

ORD record
ord-1fa002f5fe954eeab9aea0e5f4470224
Source dataset
uspto-grants-2003_11
Patent number
US06642264B1

Reaction notes

Loading…