4-Methoxyphenol → 4-Methoxy-2-(3'-(trifluoromethyl)benzyl)phenol

HRID 478891Notes

Reaction equation

HRID 478891 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[F:10][C:11]([F:21])([F:20])[C:12]1[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=1)[CH2:15]Cl>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[C:5]([CH2:15][C:14]2[CH:17]=[CH:18][CH:19]=[C:12]([C:11]([F:10])([F:20])[F:21])[CH:13]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 90154-MethoxyphenolHCID 697163-(Trifluoromethyl)benzyl chloride

Product 1

HCID 223252004-Methoxy-2-(3'-(trifluoromethyl)benzyl)phenol

Procedure

Alkylation of 4-methoxyphenol with 3-(trifluoromethyl)benzyl chloride according to the procedure described in J. Chem. Soc. 2431 (1958) gave 4-methoxy-2-(3′-(trifluoromethyl)benzyl)phenol. This material was converted to compound 67, mp 226.5-228° C., and compound 68, mp 188-190° C., byu the procedure similar to that in Example 18 method B.

Sources & evidence

ORD record
ord-ff443a482f5e49f8952470973ab25671
Source dataset
uspto-grants-2003_11
Patent number
US06642268B2

Reaction notes

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