Hydrochloric Acid → HCID 18002792, compound

HRID 478902Notes

Reaction equation

HRID 478902 reaction equation
[N:1]([CH2:4][C:5]([C:7]1[CH:16]=[CH:15][C:10]2[NH:11][C:12](=[O:14])[S:13][C:9]=2[CH:8]=1)=[O:6])=[N+]=[N-].[ClH:17]>CO.[Pd]>[ClH:17].[NH2:1][CH2:4][C:5]([C:7]1[CH:16]=[CH:15][C:10]2[NH:11][C:12](=[O:14])[S:13][C:9]=2[CH:8]=1)=[O:6]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 180027826-(2-azidoethanoyl)-3H-benzothiazol-2-one

Product 1

HCID 18002792HCID 18002792, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

6-(2-Azidoethanoyl)-3H-benzothiazol-2-one (0.5 g, 2.14 mmol) and Pd—C (5%, 0.17 g) in methanol (40 mL) and concentrated HCl (0.5 mL) were subjected to hydrogenation at 20 psi and 25° C. for 1 hour. The catalyst was removed by filtration through a ‘filter aid’ and the solvent removed to give 6-(2-aminoethanoyl)-3H-benzothiazol-2-one hydrochloride as a light brown solid (0.5 g, 96%).

Workup

  1. customThe catalyst was removed by filtration through a ‘
  2. filtrationfilter aid’ and the solvent
  3. customremoved

Sources & evidence

ORD record
ord-34ab6c7eec3748769e52d3860970fccd
Source dataset
uspto-grants-2003_11
Patent number
US06642256B2

Reaction notes

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