Epichlorohydrin → HCID 18002803, compound

HRID 478909Notes

Reaction equation

HRID 478909 reaction equation
[CH2:1]([CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([CH:16]1[O:18][CH2:17]1)[Cl:15]>>[Cl:15][CH2:14][CH:16]([OH:18])[CH2:17][N:11]1[CH2:12][CH2:13][CH:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 7835EpichlorohydrinHCID 317384-Benzylpiperidine

Product 1

HCID 18002803HCID 18002803, compoundYield 100%

Procedure

Treatment of amine 6 with epichlorohydrin, following the procedure described in Example 12, Step 1, gave crude 1-chloro-3-(4-benzylpiperidin-1-yl)propan-2-ol (29.03 g, >100%) as a clear, colorless oil:

Sources & evidence

ORD record
ord-586efa5b4bd345809dc6d1162bda5090
Source dataset
uspto-grants-2003_11
Patent number
US06642256B2

Reaction notes

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