HCID 18002803, compound → HCID 18002801, compound

HRID 478910Notes

Reaction equation

HRID 478910 reaction equation
Cl[CH2:2][CH:3]([OH:18])[CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1.[C:19]1(=[O:29])[NH:23][C:22](=[O:24])[C:21]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:20]12.[K]>>[CH2:11]([CH:8]1[CH2:9][CH2:10][N:5]([CH2:4][CH:3]([OH:18])[CH2:2][N:23]2[C:19](=[O:29])[C:20]3[C:21](=[CH:25][CH:26]=[CH:27][CH:28]=3)[C:22]2=[O:24])[CH2:6][CH2:7]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 18002803HCID 18002803, compoundHCID 24194345Phthalimide potassium salt

Product 1

HCID 18002801HCID 18002801, compoundYield 86%

Procedure

Treatment of 1-chloro-3-(4-benzylpiperidin-1-yl)propan-2-ol with potassium phthalimide, following the procedure described in Example 12, Step 2, gave 2-[3-(4-benzylpiperidin-1-yl)-2-hydroxypropyl]isoindole-1,3-dione (32.44 g, 86%) as a white solid:

Sources & evidence

ORD record
ord-1c6e39370e2446d89abbbce3be43b878
Source dataset
uspto-grants-2003_11
Patent number
US06642256B2

Reaction notes

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