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HRID478938

反应详情

EQUATION

反应方程式

HRID 478938 的结构方程式

REACTANTS

反应物

3
结构：CSC(=N)N
HCID5142

Carbamimidothioic acid methyl ester

C2H6N2S

结构：COC(=N)N
HCID75544

O-Methylisourea methyl carbamimidate

C2H6N2O

结构：NCCCC(=O)O.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@@H]3O[C@H](CN)[C@H](O)[C@@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O
HCID131724201

未命名化合物

PRODUCTS

生成物

1
结构：N=C(N)NCCCC(=O)O.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@@H]3O[C@H](CN)[C@H](O)[C@@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O
HCID178512978

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

For guanylation, the neomycin B/γ-amino butyric acid conjugate obtained in Example 9a above is treated with O-methyl isourea or S-methyl isothiourea in water at basic pH for 34 days, resulting in guanylation of the terminal amino groups. The product is purified by ion exchange chromatography, yielding the neomycin B/γ-guanidino butyric acid conjugate 17.

WORKUP

后处理

  1. customresulting in guanylation of the terminal amino groups
  2. customThe product is purified by ion exchange chromatography