HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-2-thiopseudourea → neomycin B gamma-guanidino butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-2-thiopseudourea | HCID 5142 | — |
| Reactant | O-Methylisourea | HCID 75544 | — |
| Reactant | neomycin B gamma-amino butyric acid | HCID 131724201 | — |
| Solvent | Water | HCID 962 | — |
| Product | neomycin B gamma-guanidino butyric acid | HCID 178512978 | — |
Reaction Steps
For guanylation, the neomycin B/γ-amino butyric acid conjugate obtained in Example 9a above is treated with O-methyl isourea or S-methyl isothiourea in water at basic pH for 34 days, resulting in guanylation of the terminal amino groups. The product is purified by ion exchange chromatography, yielding the neomycin B/γ-guanidino butyric acid conjugate 17.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642365B1 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-c6f4edae96e8479896f6d399ccd53340 |
| Source note | uspto-grants-2003_11 |