反应详情

0.4 Gram of 2-(2-t-butyloxazol-4-yl)-3-chlorobenzoic acid was dissolved in 30 ml of tetrahydrofuran, then 0.3 g of 2-methyl-4-trifluoromethoxyaniline, 0.4 g of DEPC and 0.3 g of triethylamine were added thereto, the resulting mixture was heated under reflux for 3 hours with stirring. After completion of the reaction, the reaction mixture was poured into water, and the objective product was extracted with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate, the residue obtained by removal of the solvent by distillation under reduced pressure was purified by the silica gel column chromatography to obtain 0.18 g (yield: 28%) of the objective product.

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 3 hours
3. customAfter completion of the reaction
4. extractionthe objective product was extracted with ethyl acetate
5. dry with materialthe organic layer was dried over anhydrous sodium sulfate
6. customthe residue obtained by removal of the solvent by distillation under reduced pressure
7. customwas purified by the silica gel column chromatography