Acetone → 1-(1-Hydroxy-2-methylpropan-2-yl)-3,3,5,5-tetramethylpiperazin-2-one

HRID 478975Notes

Reaction equation

[NH2:1][C:2]([CH3:11])([CH3:10])[CH2:3][NH:4][C:5]([CH3:9])([CH3:8])[CH2:6]O.[CH:12](Cl)(Cl)Cl.[CH3:16][C:17]([CH3:19])=O.[OH-:20].[Na+].[OH2:22]>>[OH:20][CH2:6][C:5]([N:4]1[CH2:16][C:17]([CH3:19])([CH3:12])[NH:1][C:2]([CH3:11])([CH3:10])[C:3]1=[O:22])([CH3:9])[CH3:8]

Participants

Reactant 5

HCID 180Acetone

HCID 962Water

HCID 6212Chloroform

HCID 14798Sodium Hydroxide

HCID 2268422-[(2-amino-2-methylpropyl)amino]-2-methylpropan-1-ol

Product 1

HCID 125809981-(1-Hydroxy-2-methylpropan-2-yl)-3,3,5,5-tetramethylpiperazin-2-one

Procedure

Following the procedure described in Example 1C, 80 g (0.5 moles) of 2-(2-amino-2-methyl-propylamino)-2-methyl-propan-1-ol are reacted with 90 g (0.75 moles) of chloroform and 444 ml of acetone in the presence of 114 g (2.85 moles) of sodium hydroxide in 114 ml of water.

Sources & evidence

ORD record: ord-ee84b68bffdb44d3b7a64d9e66fa960a
Source dataset: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06642383B2

Reaction notes

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