HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 1-(1-Hydroxy-2-methylpropan-2-yl)-3,3,5,5-tetramethylpiperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-[(2-amino-2-methylpropyl)amino]-2-methylpropan-1-ol | HCID 226842 | — |
| Product | 1-(1-Hydroxy-2-methylpropan-2-yl)-3,3,5,5-tetramethylpiperazin-2-one | HCID 12580998 | — |
Reaction Steps
Following the procedure described in Example 1C, 80 g (0.5 moles) of 2-(2-amino-2-methyl-propylamino)-2-methyl-propan-1-ol are reacted with 90 g (0.75 moles) of chloroform and 444 ml of acetone in the presence of 114 g (2.85 moles) of sodium hydroxide in 114 ml of water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06642383B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-ee84b68bffdb44d3b7a64d9e66fa960a |
| Source note | uspto-grants-2003_11 |