Ethylene Oxide → HCID 18003347, compound

HRID 478978Notes

Reaction equation

HRID 478978 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][C:8]([CH3:11])([CH3:10])[NH:7][C:6]([CH3:13])([CH3:12])[C:5]1=[O:14].[CH2:15]1[O:17][CH2:16]1>CO.Cl>[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][C:8]([CH3:10])([CH3:11])[N:7]([CH2:15][CH2:16][OH:17])[C:6]([CH3:13])([CH3:12])[C:5]1=[O:14]

Participants

5

Reactant 2

HCID 6354Ethylene OxideHCID 21951121HCID 21951121, compound

Product 1

HCID 18003347HCID 18003347, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Conditions

Temperature
130 °C

Procedure

45.3 g (0.22 moles) of 1-(2-hydroxyethy)-3,3,5,5-tetramethyl-piperazin-2-one are dissolved in 450 ml of methanol in the presence of 2 ml of HCl 37% (% wiw). The solution is poured into an autoclave and 19.4 g (0.44 moles) of ethylene oxide are added. The solution is heated to 130° C. and maintained at 130° C. for 60 hours under stirring.

Workup

  1. additionare added
  2. temperaturemaintained at 130° C. for 60 hours

Sources & evidence

ORD record
ord-aedf39a13705406f8d2379d6c8f987d7
Source dataset
uspto-grants-2003_11
Patent number
US06642383B2

Reaction notes

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