反应详情

Into THF (70 ml) were added (R)-3-chloromandelic acid (10 g) and further, under ice-cooling and dropwise, a 1M-diborane THF solution (81.5 ml) over 2 hours, and then stirring was continued at 25° C. for 12 hours. The reaction mixture was cooled, methanol (20 ml) was added thereto over 30 minutes and then stirring was further continued for 3 hours. The resulting reaction mixture was concentrated and then the residue was recrystallized from diethyl ether to obtain a colorless oily compound mentioned above (7.3 g, 78.9%).

1. temperaturefurther, under ice-cooling
2. temperatureThe reaction mixture was cooled
3. waitover 30 minutes
4. stirringstirring
5. waitwas further continued for 3 hours
6. customThe resulting reaction mixture
7. concentrationwas concentrated
8. customthe residue was recrystallized from diethyl ether
9. customto obtain a colorless oily compound