反应详情

温度

55 °C

Carvedilol (4 g) was dissolved in 195 mL mixture of water/methanol (in a ratio 1:3 respectively) by heating the mixture under stirring in 55° C. water bath. The solution cooled to ambient temperature and left at ambient temperature without stirring for about 15 h, the crystals were filtered through a buchner and dried in a desiccator at room temperature (connected to air pump) until constant weight to yield carvedilol Form III.

1. temperatureby heating the mixture
2. temperatureThe solution cooled to ambient temperature
3. waitleft at ambient temperature
4. stirringwithout stirring for about 15 h
5. filtrationthe crystals were filtered through a buchner
6. customdried in a desiccator at room temperature (connected to air pump) until constant weight