Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Carvedilol | HCID 2585 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | Carvedilol | HCID 2585 | — |
| Product | 2-(2-Methoxyphenoxy)ethyl amine | HCID 1713005 | — |
Reaction Steps
Carvedilol (4 g) was dissolved in 195 mL mixture of water/methanol (in a ratio 1:3 respectively) by heating the mixture under stirring in 55° C. water bath. The solution cooled to ambient temperature and left at ambient temperature without stirring for about 15 h, the crystals were filtered through a buchner and dried in a desiccator at room temperature (connected to air pump) until constant weight to yield carvedilol Form III.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06699997B2 |
|---|
| Source dataset | uspto-grants-2004_03 |
|---|
| ORD ID | ord-6a41a9615c514b78a4a3ff9d034e5297 |
|---|
| Source note | uspto-grants-2004_03 |
|---|
