HCID 10272779, compound → HCID 18003512, compound

HRID 479152Notes

Reaction equation

HRID 479152 reaction equation
[CH2:1]([O:3]/[C:4](=[CH:8]\[C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][C:18]2[N:19]=[C:20]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:21][C:22]=2[CH3:23])=[CH:11][C:10]=1[CH3:30])/[C:5]([OH:7])=[O:6])[CH3:2]>CO.[Pd]>[CH2:1]([O:3][CH:4]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][C:18]2[N:19]=[C:20]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[O:21][C:22]=2[CH3:23])=[CH:11][C:10]=1[CH3:30])[C:5]([OH:7])=[O:6])[CH3:2]

Participants

4

Reactant 1

HCID 10272779HCID 10272779, compound

Product 1

HCID 18003512HCID 18003512, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 100 mg of 2Z-ethoxy-3-{2-methyl-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-acrylic acid and 26 mg of Pd/C (10%) in 2 ml of MeOH was hydrogenated at 22° C./1 bar for 2 d. The suspension was filtered, the filtrate evaporated and dried to give 89 mg (89%) of the title compound as a pale yellow solid.

Workup

  1. customwas hydrogenated at 22° C.
  2. customfor 2 d
  3. filtrationThe suspension was filtered
  4. customthe filtrate evaporated
  5. customdried

Sources & evidence

ORD record
ord-f7bfa7c2dd3d4de4848442eaadf05616
Source dataset
uspto-grants-2003_11
Patent number
US06642389B2

Reaction notes

Loading…