Hydrochloric Acid → 2Z-ethoxy-3-{7-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-indan-4-yl}-acrylic acid

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Reaction Steps

2Z-Ethoxy-3-{7-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-indan-4-yl}-acrylic acid ethyl ester (example 91 c]) (150 mg, 0.325 mmol ) was dissolved in 1.7 ml of dioxane, 0.9 ml of water were added and LiOH (0.812 ml of a 1N solution in water, 0.813 mmol) was then added slowly at room temperature. The resulting mixture was stirred overnight at room temperature. It was then poured onto ice, neutralized to pH 4 with HCl (1N) and extracted 3 times with AcOEt. The combined organic phases were washed with water, dried over magnesium sulfate and evaporated to give 140 mg (99.4%) of 2Z-ethoxy-3-{7-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-indan-4-yl}-acrylic acid as colorless crystals.

Provenance & Evidence