反应详情

2Z-Ethoxy-3-{7-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-indan-4-yl}-acrylic acid ethyl ester (example 91 c]) (150 mg, 0.325 mmol ) was dissolved in 1.7 ml of dioxane, 0.9 ml of water were added and LiOH (0.812 ml of a 1N solution in water, 0.813 mmol) was then added slowly at room temperature. The resulting mixture was stirred overnight at room temperature. It was then poured onto ice, neutralized to pH 4 with HCl (1N) and extracted 3 times with AcOEt. The combined organic phases were washed with water, dried over magnesium sulfate and evaporated to give 140 mg (99.4%) of 2Z-ethoxy-3-{7-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-indan-4-yl}-acrylic acid as colorless crystals.

1. additionIt was then poured onto ice
2. extractionextracted 3 times with AcOEt
3. washThe combined organic phases were washed with water
4. dry with materialdried over magnesium sulfate
5. customevaporated