Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Carvedilol | HCID 2585 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | Carvedilol | HCID 2585 | — |
| Product | 2-(2-Methoxyphenoxy)ethyl amine | HCID 1713005 | — |
| Product | 4-Oxiranylmethoxy-9H-carbazole | HCID 5020710 | — |
Reaction Steps
Carvedilol (4 g) was dissolved in 267 mL dioxane/water in the ratio 1:1.4 respectively by heating the mixture under stirring at 55° C. water bath. The resulting solution was left at room temperature without stirring for about 15 h then the crystals were filtered through a buchner funnel and dried in a desiccator (connected to air pump) until constant weight to yield Carvedilol Form III in a mixture with Carvedilol Form II.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06699997B2 |
|---|
| Source dataset | uspto-grants-2004_03 |
|---|
| ORD ID | ord-64493faf84f3485f91f7ee7b65141eee |
|---|
| Source note | uspto-grants-2004_03 |
|---|
