反应详情

温度

65 °C

Carvedilol (40 g) was dissolved in 150 ml of ethanol and 40 ml water. The solution was heated with agitation to 60-70° C. until the solid material was completely dissolved. The solution is then cooled with agitation to 10° C. over a period of 3 hours. After stirring the suspension for an additional 2.75 hours, the product is filtered. Pure Carvedilol Form III (35 g) was obtained.

1. dissolutionwas completely dissolved
2. temperatureThe solution is then cooled with agitation to 10° C. over a period of 3 hours
3. filtrationthe product is filtered