反应详情

To a solution of 12.5 g (0.1 mol) of 4,4-dimethyl-3-oxopentanenitrile in 50 cm3 of n-propanol were added, at room temperature, 4.6 g (0.1 mol) of methylhydrazine. The reaction medium was maintained at reflux for 1 hour and then cooled to room temperature. The white solid obtained was filtered off on a sinter funnel and then washed with isopropyl ether. After drying under vacuum at 40° C., 10 g of the expected product were obtained in the form of a beige solid, the melting point of which was 157° C.

1. temperatureThe reaction medium was maintained
2. temperatureat reflux for 1 hour
3. customThe white solid obtained
4. filtrationwas filtered off on a sinter funnel
5. washwashed with isopropyl ether
6. customAfter drying under vacuum at 40° C.