反应详情

A mixture of 4-(4-trifluoromethylphenyl)-2-oxazolone (10.8 g), methyl acrylate (8.10 g), boron trifluoride diethyl ether complex (6.68 g) and toluene (50 mL) was stirred with heating under reflux for 3 h. The reaction mixture was concentrated and poured into iced water (200 mL). The precipitated solid was collected by filtration, washed with water and air-dried. Recrystallization from isopropyl alcohol-isopropyl ether gave the title compound as pale-yellow prism crystals (4.00 g, 27%). melting point: 156-157° C.

1. temperaturewith heating
2. temperatureunder reflux for 3 h
3. concentrationThe reaction mixture was concentrated
4. additionpoured into iced water (200 mL)
5. filtrationThe precipitated solid was collected by filtration
6. washwashed with water
7. customair-dried
8. customRecrystallization from isopropyl alcohol-isopropyl ether