反应详情

温度

90 °C

To a mixture of methyl 4-(4-chlorophenyl)-2-oxo-4-oxazoline-5-propionate (823.7 g) and phosphorus oxychloride (1090 mL) was added pyridine (235.5 mL) and the mixture was stirred at 90° C. for 8 h and allowed to stand overnight at room temperature. A solution obtained by diluting the obtained mixture with acetonitrile (2471 mL) was added dropwise to water (8237 mL) at not higher than 35° C. Then water (4119 mL) was added and the precipitated crystals were collected by filtration to give the title compound (805.4 g, yield: 91.7%).

1. waitto stand overnight at room temperature
2. customA solution obtained
3. filtrationthe precipitated crystals were collected by filtration