反应详情

A mixture of 2-bromo-4′-trifluoromethylacetophenone (40.0 g), sodium formate (40.0 g) and methanol (200 mL) was heated under reflux and stirred for 6 h. The reaction mixture was concentrated and poured into water (500 mL). The precipitated solid was collected by filtration, washed with water and air-dried to give the title compound as crystals (24.5 g, 80%). melting point: 112-114° C.

1. temperaturewas heated
2. temperatureunder reflux
3. concentrationThe reaction mixture was concentrated
4. additionpoured into water (500 mL)
5. filtrationThe precipitated solid was collected by filtration
6. washwashed with water
7. customair-dried