Hydrochloric Acid → HCID 18770417, compound

HRID 479397Notes

Reaction equation

HRID 479397 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6](/[CH:14]=[CH:15]/[CH:16]=[CH:17]/[C:18]([N:20]2[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][N:28]3[CH2:33][CH2:32][N:31]([C:34](=[O:51])/[CH:35]=[CH:36]/[CH:37]=[CH:38]/[C:39]4[CH:44]=[C:43]([O:45][CH3:46])[C:42]([O:47][CH3:48])=[C:41]([O:49][CH3:50])[CH:40]=4)[CH2:30][CH2:29]3)[CH2:22][CH2:21]2)=[O:19])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[ClH:1].[CH3:46][O:45][C:43]1[CH:44]=[C:39](/[CH:38]=[CH:37]/[CH:36]=[CH:35]/[C:34]([N:31]2[CH2:32][CH2:33][N:28]([CH2:27][CH2:26][N:23]3[CH2:22][CH2:21][N:20]([C:18](=[O:19])/[CH:17]=[CH:16]/[CH:15]=[CH:14]/[C:6]4[CH:7]=[C:8]([O:12][CH3:13])[C:9]([O:10][CH3:11])=[C:4]([O:3][CH3:2])[CH:5]=4)[CH2:25][CH2:24]3)[CH2:29][CH2:30]2)=[O:51])[CH:40]=[C:41]([O:49][CH3:50])[C:42]=1[O:47][CH3:48]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12988314HCID 12988314, compound

Product 1

HCID 18770417HCID 18770417, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.050 ml; 0.60 mmol) was added to a solution in ethanol (5 ml) of 1,2-bis[4-[(E,E)-5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-1-piperazinyl]ethane (128 mg; 0.19 mmol) synthesized in the above process and the reaction mixture was concentrated under reduced pressure. After a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice, the resultant concentrated residue was recrystallized from methanol-diethyl ether to obtain the title compound as a pale yellow crystalline powder.

Workup

  1. customsynthesized in the above process
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. concentrationAfter a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
  4. customthe resultant concentrated residue was recrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-9b507994bc474e3fad33f7a74a407be2
Source dataset
uspto-grants-2003_11
Patent number
US06645957B2

Reaction notes

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