Hydrochloric Acid → HCID 18770397, compound
Reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:55]=[CH:54][C:17]([C:18]([N:20]3[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][N:28]4[CH2:33][CH2:32][N:31]([C:34](=[O:53])[C:35]5[CH:40]=[CH:39][C:38]([C:41]6[CH:46]=[C:45]([O:47][CH3:48])[C:44]([O:49][CH3:50])=[C:43]([O:51][CH3:52])[CH:42]=6)=[CH:37][CH:36]=5)[CH2:30][CH2:29]4)[CH2:22][CH2:21]3)=[O:19])=[CH:16][CH:15]=2)[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[ClH:1].[CH3:48][O:47][C:45]1[CH:46]=[C:41]([C:38]2[CH:37]=[CH:36][C:35]([C:34]([N:31]3[CH2:32][CH2:33][N:28]([CH2:27][CH2:26][N:23]4[CH2:24][CH2:25][N:20]([C:18](=[O:19])[C:17]5[CH:16]=[CH:15][C:14]([C:6]6[CH:7]=[C:8]([O:12][CH3:13])[C:9]([O:10][CH3:11])=[C:4]([O:3][CH3:2])[CH:5]=6)=[CH:55][CH:54]=5)[CH2:21][CH2:22]4)[CH2:29][CH2:30]3)=[O:53])=[CH:40][CH:39]=2)[CH:42]=[C:43]([O:51][CH3:52])[C:44]=1[O:49][CH3:50]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (0.028 ml; 0.34 mmol) was added to a solution of 1,2-bis[4-[4-(3,4,5-trimethoxyphenyl)benzoyl]-1-piperazinyl]ethane (84 mg; 0.11 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. A process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice. The resultant crude crystals were suspended in methanol and collected by filtration to obtain the title compound as a colorless crystalline powder.
Workup
- concentrationthe reaction mixture was concentrated under reduced pressure
- concentrationA process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
- filtrationcollected by filtration
Sources & evidence
- ORD record
- ord-c48d7a583b1b4afaa7ca47432ef590c8
- Source dataset
- uspto-grants-2003_11
- Patent number
- US06645957B2
Reaction notes
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