反应详情

Concentrated hydrochloric acid (0.015 ml; 0.18 mmol) was added to a solution of 1,3-bis[4-[4-(3,4,5-trimethoxyphenyl)benzoyl]-1-piperazinyl]propane (43 mg; 0.050 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. After a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice, the resultant concentrated residue was recrystallized from methanol-diethyl ether to obtain the title compound as a colorless crystalline powder.

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. concentrationAfter a process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
3. customthe resultant concentrated residue was recrystallized from methanol-diethyl ether