Hydrochloric Acid → HCID 18770425, compound
Reaction equation
[ClH:1].[N+:2]([C:5]1[CH:6]=[CH:7][C:8]([C:51]2[CH:56]=[C:55]([O:57][CH3:58])[C:54]([O:59][CH3:60])=[C:53]([O:61][CH3:62])[CH:52]=2)=[C:9]([CH:50]=1)[C:10]([N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][N:24]([C:27](=[O:49])[C:28]3[CH:33]=[C:32]([N+:34]([O-:36])=[O:35])[CH:31]=[CH:30][C:29]=3[C:37]3[CH:42]=[C:41]([O:43][CH3:44])[C:40]([O:45][CH3:46])=[C:39]([O:47][CH3:48])[CH:38]=3)[CH2:23][CH2:22]2)[CH2:14][CH2:13]1)=[O:11])([O-:4])=[O:3]>C(O)C>[ClH:1].[ClH:1].[N+:34]([C:32]1[CH:31]=[CH:30][C:29]([C:37]2[CH:42]=[C:41]([O:43][CH3:44])[C:40]([O:45][CH3:46])=[C:39]([O:47][CH3:48])[CH:38]=2)=[C:28]([CH:33]=1)[C:27]([N:24]1[CH2:25][CH2:26][N:21]([CH2:20][CH2:19][CH2:18][N:15]2[CH2:14][CH2:13][N:12]([C:10](=[O:11])[C:9]3[CH:50]=[C:5]([N+:2]([O-:4])=[O:3])[CH:6]=[CH:7][C:8]=3[C:51]3[CH:52]=[C:53]([O:61][CH3:62])[C:54]([O:59][CH3:60])=[C:55]([O:57][CH3:58])[CH:56]=3)[CH2:17][CH2:16]2)[CH2:22][CH2:23]1)=[O:49])([O-:36])=[O:35]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (0.090 ml; 1.1 mmol) was added to a solution of 1,3-bis[4-[5-nitro-2-(3,4,5-trimethoxyphenyl)benzoyl]-1-piperazinyl]propane (230 mg; 0.27 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. A process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice to obtain the title compound as a pale yellow amorphous powder.
Workup
- concentrationthe reaction mixture was concentrated under reduced pressure
- concentrationA process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure
Sources & evidence
- ORD record
- ord-14e4fd4fcd914813a7ddc15f5072615d
- Source dataset
- uspto-grants-2003_11
- Patent number
- US06645957B2
Reaction notes
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