Hydrochloric Acid → HCID 18770457, compound

HRID 479424Notes

Reaction equation

HRID 479424 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]#[C:15]/[CH:16]=[CH:17]/[C:18]([N:20]2[CH2:25][CH2:24][CH:23]([CH2:26][CH:27]([N:53]([CH3:55])[CH3:54])[CH2:28][CH:29]3[CH2:34][CH2:33][N:32]([C:35](=[O:52])/[CH:36]=[CH:37]/[C:38]#[C:39][C:40]4[CH:45]=[C:44]([O:46][CH3:47])[C:43]([O:48][CH3:49])=[C:42]([O:50][CH3:51])[CH:41]=4)[CH2:31][CH2:30]3)[CH2:22][CH2:21]2)=[O:19])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]>C(O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:14]#[C:15]/[CH:16]=[CH:17]/[C:18]([N:20]2[CH2:25][CH2:24][CH:23]([CH2:26][CH:27]([N:53]([CH3:55])[CH3:54])[CH2:28][CH:29]3[CH2:34][CH2:33][N:32]([C:35](=[O:52])/[CH:36]=[CH:37]/[C:38]#[C:39][C:40]4[CH:41]=[C:42]([O:50][CH3:51])[C:43]([O:48][CH3:49])=[C:44]([O:46][CH3:47])[CH:45]=4)[CH2:31][CH2:30]3)[CH2:22][CH2:21]2)=[O:19])[CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770458HCID 18770458, compound

Product 1

HCID 18770457HCID 18770457, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.035 ml; 0.42 mmol) was added to a solution of 1,3-bis[1-[(E)-5-(3,4,5-trimethoxyphenyl)-2-penten-4-ynoyl]-4-piperidinyl]-2-(dimethylamino)propane (104 mg; 0.14 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. A process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice to obtain the title compound as a pale yellow amorphous powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. concentrationA process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure

Sources & evidence

ORD record
ord-70ab71c0a6194d3e946957d3354fe31e
Source dataset
uspto-grants-2003_11
Patent number
US06645957B2

Reaction notes

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