Hydrochloric Acid → HCID 18770398, compound

HRID 479431Notes

Reaction equation

HRID 479431 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[CH:10]=[C:9](/[CH:18]=[CH:19]/[C:20]([N:22]1[CH2:27][CH2:26][CH:25]([CH2:28][N:29]([CH3:57])[CH2:30][CH:31]3[CH2:36][CH2:35][N:34]([C:37](=[O:56])/[CH:38]=[CH:39]/[C:40]4[CH:49]=[CH:48][C:47]5[C:42](=[C:43]([O:54][CH3:55])[C:44]([O:52][CH3:53])=[C:45]([O:50][CH3:51])[CH:46]=5)[CH:41]=4)[CH2:33][CH2:32]3)[CH2:24][CH2:23]1)=[O:21])[CH:8]=[CH:7]2>C(O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[CH:10]=[C:9](/[CH:18]=[CH:19]/[C:20]([N:22]1[CH2:27][CH2:26][CH:25]([CH2:28][N:29]([CH3:57])[CH2:30][CH:31]3[CH2:36][CH2:35][N:34]([C:37](=[O:56])/[CH:38]=[CH:39]/[C:40]4[CH:49]=[CH:48][C:47]5[C:42](=[C:43]([O:54][CH3:55])[C:44]([O:52][CH3:53])=[C:45]([O:50][CH3:51])[CH:46]=5)[CH:41]=4)[CH2:33][CH2:32]3)[CH2:24][CH2:23]1)=[O:21])[CH:8]=[CH:7]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18770391HCID 18770391, compound

Product 1

HCID 18770398HCID 18770398, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.020 ml; 0.24 mmol) was added to a solution of N,N-bis[[1-[(E)-3-(6,7,8-trimethoxy-2-naphthyl)-2-propenoyl]-4-piperidinyl]methyl]methylamine (57 mg; 0.074 mmol) in ethanol (5 ml) and the reaction mixture was concentrated under reduced pressure. A process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure was performed twice to obtain the title compound as a pale yellow amorphous powder.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. concentrationA process of adding ethanol (10 ml) to the residue and concentrating the mixture under reduced pressure

Sources & evidence

ORD record
ord-86fc3c353ed84fa08f73084507d4041c
Source dataset
uspto-grants-2003_11
Patent number
US06645957B2

Reaction notes

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