Hydrochloric Acid → HCID 178512349, compound

HRID 479519Notes

Reaction equation

HRID 479519 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].Cl.[N-:13]([C:16]#[N:17])[C:14]#[N:15].[Na+]>O>[C:14]([N:13]=[C:16]([NH2:17])[NH:6][C:5]1[CH:7]=[CH:8][CH:9]=[C:3]([C:2]([F:10])([F:11])[F:1])[CH:4]=1)#[N:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 73753-(Trifluoromethyl)anilineHCID 4350929Sodium dicyanamide

Product 1

HCID 178512349HCID 178512349, compoundYield 86.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-Trifluoromethylaniline (10 g, 62.1 mmol) was dissolved in 6N HCl (10.35 mmol, 62.1 mmol) and 50 ml of water. Sodium dicyanamide (5.53 g, 62.1 mmol) was added and the mixture was stirred for 12 hours at ambient temperature. The mixture was then cooled to 0° C. and stirred for 1 hour resulting in the formation of a precipitate. Filtration provided 12.22 g of the desired product as a white solid.

Workup

  1. temperatureThe mixture was then cooled to 0° C.
  2. stirringstirred for 1 hour
  3. customresulting in the formation of a precipitate
  4. filtrationFiltration

Sources & evidence

ORD record
ord-721d0d4fe3f744e2b63334a6b04d64a7
Source dataset
uspto-grants-2003_11
Patent number
US06645968B2

Reaction notes

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