p-Toluenesulfonic acid → HCID 18770516, compound

HRID 479534Notes

Reaction equation

HRID 479534 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.[CH3:11][C:12]([CH:15]=O)([CH3:14])[CH3:13].[NH:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:17]1([CH:15]([NH:8][C:6](=[O:7])[C:5]2[CH:9]=[CH:10][C:2]([Br:1])=[CH:3][CH:4]=2)[C:12]([CH3:13])([CH3:14])[CH3:11])[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 12417PivalaldehydeHCID 696834-BromobenzamideHCID 178418385HCID 178418385, compound

Product 1

HCID 18770516HCID 18770516, compound

Procedure

4-Bromobenzamide, pivaldehyde, benzotriazole, and p-toluenesulfonic acid were processed as described in Example 53A to provide the desired product.

Sources & evidence

ORD record
ord-631476c5ba4946ea854556b8f56529f1
Source dataset
uspto-grants-2003_11
Patent number
US06645968B2

Reaction notes

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