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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 479538Generated: October 26, 2026

p-Toluenesulfonic acid → n-(1-(1h-1,2,3-Benzotriazol-1-yl)-2,2-dimethylpropyl)-3,5-difluorobenzamide

https://huagongshe.com/reaction/479538

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Toluenesulfonic acidHCID 6101—
ReactantPivalaldehydeHCID 12417—
Reactant3,5-DifluorobenzamideHCID 2736910—
ReactantHCID 178418385HCID 178418385—
Productn-(1-(1h-1,2,3-Benzotriazol-1-yl)-2,2-dimethylpropyl)-3,5-difluorobenzamideHCID 18770765—

Reaction Steps

3,5-Difluorobenzamide, pivaldehyde, benzotriazole and p-toluenesulfonic acid were processed as described in Example 53A to provide the desired product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06645968B2
Source datasetuspto-grants-2003_11
ORD IDord-e0d2b190b10f48168d729451c0809585
Source noteuspto-grants-2003_11