p-Toluenesulfonic acid → n-(1-(1h-1,2,3-Benzotriazol-1-yl)-2,2-dimethylpropyl)-3,5-difluorobenzamide

HRID 479538Notes

Reaction equation

HRID 479538 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5]([NH2:7])=[O:6].[CH3:12][C:13]([CH:16]=O)([CH3:15])[CH3:14].[NH:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:18]1([CH:16]([NH:7][C:5](=[O:6])[C:4]2[CH:3]=[C:2]([F:1])[CH:10]=[C:9]([F:11])[CH:8]=2)[C:13]([CH3:14])([CH3:15])[CH3:12])[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 12417PivalaldehydeHCID 27369103,5-DifluorobenzamideHCID 178418385HCID 178418385, compound

Product 1

HCID 18770765n-(1-(1h-1,2,3-Benzotriazol-1-yl)-2,2-dimethylpropyl)-3,5-difluorobenzamide

Procedure

3,5-Difluorobenzamide, pivaldehyde, benzotriazole and p-toluenesulfonic acid were processed as described in Example 53A to provide the desired product.

Sources & evidence

ORD record
ord-e0d2b190b10f48168d729451c0809585
Source dataset
uspto-grants-2003_11
Patent number
US06645968B2

Reaction notes

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